Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? CMAJ cmaj.120951 published ahead of print November 26, 2012Ĥ. Also, your medicine container may have a sticker, warning of potential grapefruit interactions.ĭrug interactions are one of the reasons it’s important to tell your doctor and pharmacist of any vitamins, herbal or food supplements you are taking. This can be found in the medicines packet, or you can search for your medicine’s CMI online here. This should also be stated in the Consumer Medicines Information leaflet for your medicine. Your pharmacist or doctor will be able to advise you whether grapefruit or grapefruit juice will interact with your medicine. How do I know if grapefruit juice will interact with my medicine? Sildenafil ( Viagra) used for erectile dysfunction.Calcium channel blockers, such as felodipine (e.g.Telfast) – in this case blood levels of fexofenadine go down and it becomes less effective. Some antihistamines, such as fexofenadine (e.g.Here are some common medicines that may interact with grapefruit. Lipitor) – the common lipid-lowering statin drug – is one of them. Research has shown that more than 85 medicines can interact with grapefruit, with 43 of them having potentially serious or deadly consequences. Common medicines that grapefruit juice interacts with Seville (or bitter) orange juice and limes may also cause the same effects as grapefruit. Consuming it regularly will make the chance of significant interactions more likely. The effect of grapefruit juice on some medicines can last for over 24 hours. It can happen even when the grapefruit is consumed at a different time from the medicine. Just one glass of grapefruit juice or one serve of grapefruit is all it takes to interfere with your medicine. These increased blood levels of your medicine can be dangerous and may increase the effect of your medicine until there are potentially serious consequences.įor example, if a person taking some blood-pressure medicines consumes grapefruit, the concentration of their blood pressure medicines will rise in their body, and result in their blood pressure becoming dangerously lowered. So grapefruit and grapefruit juice interactions often lead to an increase in the amount of medicine circulating in your body. Grapefruit juice interferes with enzymes responsible for breaking down medicines in the body. How does grapefruit juice interact with medicines? The interaction may result in the effect of the medicine becoming stronger or weaker or in a change in side-effects of the medicine. ![]() Interactions are when something interferes with how a medicine works. ![]() Grapefruit is just one of many foods that can cause interactions with medicines.
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